Download Acute Leukemias: Pharmacokinetics and Management of Relapsed by A. F. List, C. M. Spier, W. S. Dalton (auth.), Prof. Dr. W. PDF

By A. F. List, C. M. Spier, W. S. Dalton (auth.), Prof. Dr. W. Hiddemann, Prof. Dr. T. Büchner, Priv. Doz. Dr. B. Wörmann, Prof. Dr. W. Plunkett, Prof. Dr. M. Keating, Prof. Dr. M. Andreeff (eds.)

ISBN-10: 3540539492

ISBN-13: 9783540539490

This can be the 3rd quantity during this sequence on equipment of treating acute leukemia. a number of drug resistance is mentioned, besides using human granulocyte-macrophage CSF, the position of stem telephone issue, and uncomplicated elements of phone biology and pharmakokinetics. there's additionally a entire part facing relapse treatment and postremission treatment. The publication therefore presents the clinician with guidance to be used in daily perform.

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Additional resources for Acute Leukemias: Pharmacokinetics and Management of Relapsed and Refractory Disease

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In the presence ofMTX, at concentrations that retarded growth only slightly, DHFR increased markedly during logarithmic growth and persisted during plateau phase. 0) did not increase as compared to control cells. That the increased concentration of total reductase was due to decreased degradation of the enzyme was supported by experiments in which actinomycin D and cycloheximide were used [36]. However, it is also possible that an enhanced rate of expression of DHFR mRNA contributes to this increase.

Acad Sci USA 80: 807-809 11. Horns RC, Dower WJ, Schimke RT (1984) Gene amplification in a leukemia patient treated with methotrexate. J Clin Oncol 2: 2-7 12. Carman MD, Schornagel JH, Rivest RS, Srimatkandada S, Portlock CS, Bertino JR (1984) Clinical resistance to methotrexate due to gene amplification. J Clin Oncol 2: 16-20 13. Curt GA, Carney DN, Cowan KH, Jolivet J, Bailey BD, Drake JC, Kao-Shan CS, Minna 21 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 22 JD, Chabner BA (1983) Unstable methotrexate resistance in human small cell cancer associated with double minute chromosomes.

Dalton WS, Grogan TM, Meltzer PS, Scheper RJ, Durie BGM, Taylor CW, Miller TP, Salmon SE (1989) Drug-resistance in multi- 10 pie myeloma and non-Hodgkin's lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy. J Clin Oncol 7: 415-424 45. Meador J, Sweet P, Stupecky M, et al. (1987) Enhancement by Cyclosporin-A of daunorubicin efficacy in Ehlich ascites carcinoma and murine hepatoma 129. Cancer Res 47: 6216-6219 The Role of DNA Topoisomerase II in Multidrug Resistance in Human Leukemia W T.

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