Download Adrenomedullin in Cardiovascular Disease by Kazuo Kitamura, Kenji Kangawa, Tanenao Eto (auth.), Toshio PDF

By Kazuo Kitamura, Kenji Kangawa, Tanenao Eto (auth.), Toshio Nishikimi MD, PhD (eds.)

ISBN-10: 0387254048

ISBN-13: 9780387254043

Adrenomedullin was once came across in 1993 in an extract of human pheochromocytoma whereas tracking cAMP degrees in rat platelets. Adrenomedullin has attracted massive curiosity between cardiologists as a result of its influence at the cardiovascular procedure which incorporates a reduce in blood strain in vivo; an effect on vascular gentle muscle cells; raises cAMP degrees; ultimately reduces blood strain and has a task within the pathogenesis of arteriosclerosis.

Adrenomedullin in heart problems is an updated overview of the main correct points of adrenomedullin. It contains a vast diversity of fields together with biochemistry, molecular biology, body structure, pharmacology, pathophysiology of heart problems and scientific purposes of adrenomedullin to cardiovascular disease.

Toshio Nishikimi, MD, PhD, is an affiliate Professor within the division of high blood pressure and Cardiorenal medication, Dokkyo college institution of medication, Tochigi, Japan.

Show description

Read or Download Adrenomedullin in Cardiovascular Disease PDF

Similar cardiovascular books

Interdisciplinary Concepts in Cardiovascular Health: Volume II: Secondary Risk Factors

This ebook presents an advent to the rules of either cardiovascular epidemiology and molecular pathophysiology; as a special point, it additionally outlines and discusses the molecular ideas underlying epidemiological observations. This moment quantity is targeted on all elements touching on “secondary chance elements” when it comes to ailments linked to more advantageous chance for cardiovascular occasions.

Morphology and Function in MRI: Cardiovascular and Renal Systems

MRI has spread out new percentages in mixed morphological and practical imaging, and now there's a e-book which discusses either facets jointly. structures which already exhibit the benefits of MRI are awarded. within the cardiovascular approach, movement and circulate should be imaged in order that even move velocities within the deep vessels of the physique should be measured, and turbulences might be pointed out.

Extra info for Adrenomedullin in Cardiovascular Disease

Example text

Furthermore, AM rapidly and transiently stimulated ERK activities; the AM-induced mitogenic effect and ERK activation was completely blocked by a MEK inhibitor (PD98059) and a protein tyrosine kinase (PTK) inhibitor (genestein). Our data strongly suggest that the mitogenic effect of AM on VSMCs is mediated via PTK/ERK pathway. It is of note that a cAMP antagonist (Rp-cAMP-S) and a highly selective PKA inhibitor (KT5720) failed to inhibit the mitogenic effect and ERK activation by AM, despite of the AM-mediated cAMP response.

Prado MA, Evans-Bain B, Oliver KR, and Dickerson IM. (2001) The role of the CGRP-receptor component protein (RCP) in adrenomedullin receptor signal transduction. Peptides 22:1773-1781. Rebuffat P, Forneris ML, Aragona F, Ziolkowska A, Malendowicz LK, and Nussdorfer GG. (2002) Adrenomedullin and its receptors are expressed in the zona glomerulosa of human adrenal gland: evidence that ADM enhances proliferation and decreases apoptosis in cultured ZG cells. Int J MolMed 9:119-124. Segawa K, Minami K, Sata T, Kuroiwa A, and Shigematsu A.

Muff R, Buhlmann N, Fischer JA, and Born W. (1999) An amylin receptor is revealed following co-transfection of a calcitonin receptor with receptor activity modifying proteins-1 or-3. Endocrinology 140:2924-2927. Nishimatsu H, Suzuki E, Nagata D, Moriyama N, Satonaka H, Walsh K, Sata M, Kangawa K, Matsuo H, Goto A, Kitamura T, and Hirata Y (2001) Adrenomedullin induces endothelium-dependent vasorelaxation via the phosphatidylinositol 3-kinase/Akt-dependent pathway in rat aorta. Circ Res 89:63-70.

Download PDF sample

Rated 4.69 of 5 – based on 29 votes