Download AMP-activated Protein Kinase by Mario D. Cordero, Benoit Viollet PDF

By Mario D. Cordero, Benoit Viollet

ISBN-10: 3319435892

ISBN-13: 9783319435893

AMPK has emerged as an immense integrator of indications that keep an eye on power stability in the course of the legislation of a number of biochemical pathways in eukaryotes.

This e-book specializes in the results of AMPK as a grasp metabolic regulator in illnesses, together with new equipment and animal versions. The contributions are written by means of best specialists within the box and provides an in depth evaluate of the present wisdom of AMPK biology and the function of AMPK in healthiness and ailment.

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D. Cordero, B. 1007/978-3-319-43589-3_2 23 24 Y. Angin et al. 1 Historical Background The AMP-activated protein kinase (AMPK) has an important place in the regulation of signaling pathways involved in energy and substrate metabolism. AMPK senses cellular energy status by monitoring ADP/ATP and AMP/ATP ratios and nutrient availability and regulates cellular events by stimulating ATP-generating cellular processes (such as glucose uptake, glycolysis, and fatty acid oxidation) while inhibiting ATP-consuming processes (such as fatty acid and protein synthesis) (Hardie et al.

3 Glycogen Metabolism . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Gluconeogenesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 AMPK in Lipid Metabolism . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Fatty Acid Uptake . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

24 25 26 28 29 29 30 30 30 31 33 34 34 37 Abstract This chapter summarizes AMPK function in the regulation of substrate and energy metabolism with the main emphasis on carbohydrate and lipid metabolism, protein turnover, mitochondrial biogenesis, and whole-body energy homeostasis. AMPK acts as whole-body energy sensor and integrates different signaling pathway to meet both cellular and body energy requirements while inhibiting energy-consuming processes but also activating energy-producing ones.

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