By Philip B. Mead M.D. (auth.), William J. Ledger (eds.)
The cause to arrange this quantity on antibiotics for the health care professional taking good care of ladies used to be established upon the editor's conception that the subject material had by no means been totally built for the obstetrician-gynecologist. such a lot textbooks of infectious illness have a small part dedicated to antibiotics, which has little relevance for the healthcare professional taking good care of post-operative or post-partum infections. simple antibiotic pharmacology is defined and there's a reflex prohibition of antibiotics for the pregnant lady. appropriately, the reader assumes that the authors themselves don't deal with ladies with bacterial infections of the pelvis. fresh texts in infectious ailment in obstetrics gynecology were little greater. even if the focal point has been extra clini cally orientated, house specifications have too frequently saved the discussions at a superficial point. a complete concentration upon antibiotics during this quantity gets rid of the restraints of house in past courses. the best present in my activity as editor of this quantity is expounded to the standard of the person authors. they vary from former scholars, to con transitority colleagues, to revered friends in infectious ailment. because the caliber of this quantity is expounded to the sum overall of the person chapters, I desire to remark approximately all the members. Philip Mead from the college of Vermont is an outdated buddy, who brings to the query of prophylactic antibiotics, his broad medical adventure and encyclopedic knowledge.
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Additional resources for Antibiotics in Obstetrics and Gynecology
The authors state that this is 1 h longer than in healthy adult males but similar to what has been found in infected hospitalized patients. The authors believe that the difference in T 1/2 is due more to an ambulatory or hospitalized state of the patient than to pregnancy itself. This may be true, although it would be interesting to have the corresponding data for pregnant women who are not undergoing surgery. Cefacetrile has been studied in women in labor. v. to 13 patients as a continuous infusion of 500 mg/h or i.
Can Med J 118:1395, 1978 99. : Metronidazole in the prophylaxis and treatment of anaerobic infection. S Afr Med J 54:703, 1978 J(lO. Sprague AD, Van Nagell JR: The relationship of age and endometrial histology to blood loss and morbidity following vaginal hysterectomy. Am J Obstet GynecoII18:805, 1974 101. Ledger WJ, Campbell C, Willson JR: Postoperative adnexal infections. Obstet Gynecol 31:83, 1968 102. Ledger WJ, Campbell C, Taylor D, Willson JR: Adnexal abscess as a late complication of pelvic operations.
However, it is well known that infections which require antibiotic treatment are far from uncommon during pregnancy. The infection may be confined to maternal tissues only as with pharyngitis, pyelonephritis, pneumonia, or, as in the case of syphilis, involve the fetus as well. In the first case the main concern in the choice of dose and route of administration should be to obtain adequate serum and tissue levels of antibiotic in the infected maternal tissue, not so low to be ineffective in which case the patient's suffering from the infection will be prolonged, and not too high which might increase the risk of adverse effects and unduly expose the fetus.