Download Anticoagulation by J. Fareed (auth.), Dr. Christian Doutremepuich (eds.) PDF

By J. Fareed (auth.), Dr. Christian Doutremepuich (eds.)

ISBN-10: 1461276276

ISBN-13: 9781461276272

All scientific experts who needs to take care of the potential of thrombosis could be attracted to Anticoagulation. This publication evaluates anticoagulation techniques from a number of issues of view - from present traits in Anti-thrombotic medications, to therapy of Ischemic Vascular problems; from Anticoagulants in being pregnant, to Anticoagulation within the aged, from the results of Anticoagulant treatment at the middle, to Anticoagulation in quite a few surgeries. Anticoagulation is a source of methods to the administration of this universal scientific problem.

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Azougagh Oualane, F. Doutremepuich - drugs that protease. 1 Drugs factors act that on synthesis inhibit of indirectly plasmatic the serine coagulation 2 • 1. 1 Hepar ins Heparin is an anticoagulant drug discovered by Mac Lean in 1916. The fi:::st clinical trial was done in 1936. The mechanism of its anticoagulant activity was only understood in 1970. Unfractionnated heparin (UFH) is mucopolysaccharide chains of various length that range from 5000 to 30000 daltons. It is extracted from beef liver or pork intestines.

In effect heparin was discovered in 1918 [26] and for many years considered no more than an anticoagulant drug. Only 25 years after, in 1943, Hahn [21] discovered a new activity of heparin, lipoproteinolipase releasing activity. This discovery opened a new chapter in heparin field and led researchers to the separation of anticoagulant and antilipaemic activities, through chemical modifications of heparin molecules: for instance, the hepar ides [45] an the so-called heparinoids were obtained. Table I: In vitro and ex vivo characteristics of international heparin standard (WHO III), commercial heparin, dextran sulphate (DEXT-S), mucopolysaccharide pOlysulphate (MPS-PS), pentosan polysulphate (P-PS), heparamin, dermatan and heparan.

In contrast with heparin, OS does not inhibit factor Xa, and is virtually inactive in vitro as anticoagulant in conventional clotting assays. It has been showed that OS has anticoagulant activity. It is also effective as antithrombotic agent with little effect on bleeding when used at antithrombotic levels. Its anticoagulant activity is related to the degree of sulfatation. In comparison to heparin, OS causes a relatively weak prolongation of clotting time. Despite the fact that these compounds are weak anticoagulants, they are potent inhibitors of the intrinsic pathway for thrombin generation [35].

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